Z-mota Move 2.0. Interfaz basado en la monitorización del movimiento e identificación por radiofrecuencia

Proyecto que aborda la realización de un dispositivo de avanzado de control que, mediante sensores inerciales y un lector RFID (Radio Frequency IDentification), sea capaz de aportar información sobre el movimiento de la persona y del contexto que la rodea

Diseño de una unidad didáctica basada en el método de enseñanza por descubrimiento guiado , para la inclusión en la clase de educación física de estudiantes en situación de discapacidad física de miembro inferior del grado tercero del Instituto Técnico Industrial Francisco José De Caldas Sede D.

Este proyecto de investigación pretende desarrollar una unidad didáctica mediante la cual se adecue a una clase de Educación Física convencional actividades y estrategias que permitan involucrar de una forma más activa a los estudiantes de grado tercero que presentan algún grado de discapacidad física de miembro inferior en el Instituto Técnico Industrial (I.T.I) Francisco José de Caldas sede D , ya que con relación a los lineamentos curriculares de la Educación Física, el DEPORTES y la Recreación, es posible modificar las actividades de las clases dependiendo el tipo de circunstancia que ésta presente, para que así tenga un desarrollo y participación activa de los estudiantes sin importar su situación de discapacidad. A partir de esto, es necesario tener en cuenta que la unidad didáctica a desarrollar para la clase de Educación Física se plantea desde el desarrollo del método de enseñanza por DESCUBRIMIENTO GUIADO , el cual como menciona Martínez implica cognitivamente al alumno en primera instancia, constituyendo así, un paso superior a su motricidad y a su desempeño como tal, este método permite tener una relación más estrecha entre el estudiante y el maestro para una mejor comunicación. Es importante tener en cuenta que este método permite una planificación de la enseñanza de manera abierta y flexible, ya que no sigue un orden característico y trabaja o planifica comportamientos generales, gruesos pero definidos y conductas especificas, además dentro de sus objetivos expresan tanto los procesos como los productos de aprendizaje por ello se propone a los estudiantes situaciones reales que deben descubrir enfatizando en los procesos de adquisición de conceptos, solución de problemas y estrategias mentales a través del dialogo y el juego, permitiendo así que como futuros docentes seamos orientadores, asesores y amigos del estudiante para estar presente en su proceso de adaptació

Impact of operatoŕs experience on peri-procedural outcomes with Watchman FLX: Insights from the FLX-SPA registry

Background: The Watchman FLX is a device upgrade of the Watchman 2.5 that incorporates several design enhancements intended to simplify left atrial appendage occlusion (LAAO) and improve procedural outcomes. This study compares peri-procedural results of LAAO with Watchman FLX (Boston Scientific, Marlborough, Massachusetts) in centers with varying degrees of experience with the Watchman 2.5 and Watchman FLX. Methods: Prospective, multicenter, 'real-world' registry including consecutive patients undergoing LAAO with the Watchman FLX at 26 Spanish sites (FLX-SPA registry). Implanting centers were classified according to the center's prior experience with the Watchman 2.5. A further division of centers according to whether or not they had performed ≤ 10 or > 10Watchman FLX implants was prespecified at the beginning of the study. Procedural outcomes of institutions stratified according to their experience with the Watchman 2.5 and FLX devices were compared. Results: 359 patients [mean age 75.5 (SD8.1), CHA2DS2-VASc 4.4 (SD1.4), HAS-BLED 3.8(SD0.9)] were included. Global success rate was 98.6%, successful LAAO with the first selected device size was achieved in 95.5% patients and the device was implanted at first attempt in 78.6% cases. There were only 9(2.5%) major peri-procedural complications. No differences in efficacy or safety results according to the centeŕs previous experience with Watchman 2.5 and procedural volume with Watchman FLX existed. Conclusions: The Watchman FLX attains high procedural success rates with complete LAA sealing in unselected, real-world patients, along with a low incidence of peri-procedural complications, regardless of operatoŕs experience with its previous device iteration or the number of Watchman FLX devices implanted

Artificial intelligence within the interplay between natural and artificial computation:Advances in data science, trends and applications

Artificial intelligence and all its supporting tools, e.g. machine and deep learning in computational intelligence-based systems, are rebuilding our society (economy, education, life-style, etc.) and promising a new era for the social welfare state. In this paper we summarize recent advances in data science and artificial intelligence within the interplay between natural and artificial computation. A review of recent works published in the latter field and the state the art are summarized in a comprehensive and self-contained way to provide a baseline framework for the international community in artificial intelligence. Moreover, this paper aims to provide a complete analysis and some relevant discussions of the current trends and insights within several theoretical and application fields covered in the essay, from theoretical models in artificial intelligence and machine learning to the most prospective applications in robotics, neuroscience, brain computer interfaces, medicine and society, in general.BMS - Pfizer(U01 AG024904). Spanish Ministry of Science, projects: TIN2017-85827-P, RTI2018-098913-B-I00, PSI2015-65848-R, PGC2018-098813-B-C31, PGC2018-098813-B-C32, RTI2018-101114-B-I, TIN2017-90135-R, RTI2018-098743-B-I00 and RTI2018-094645-B-I00; the FPU program (FPU15/06512, FPU17/04154) and Juan de la Cierva (FJCI-2017–33022). Autonomous Government of Andalusia (Spain) projects: UMA18-FEDERJA-084. Consellería de Cultura, Educación e Ordenación Universitaria of Galicia: ED431C2017/12, accreditation 2016–2019, ED431G/08, ED431C2018/29, Comunidad de Madrid, Y2018/EMT-5062 and grant ED431F2018/02. PPMI – a public – private partnership – is funded by The Michael J. Fox Foundation for Parkinson’s Research and funding partners, including Abbott, Biogen Idec, F. Hoffman-La Roche Ltd., GE Healthcare, Genentech and Pfizer Inc

Yeast : the soul of beer’s aroma—a review of flavour-active esters and higher alcohols produced by the brewing yeast

Among the most important factors influencing beer quality is the presence of well-adjusted amounts of higher alcohols and esters. Thus, a heavy body of literature focuses on these substances and on the parameters influencing their production by the brewing yeast. Additionally, the complex metabolic pathways involved in their synthesis require special attention. More than a century of data, mainly in genetic and proteomic fields, has built up enough information to describe in detail each step in the pathway for the synthesis of higher alcohols and their esters, but there is still place for more. Higher alcohols are formed either by anabolism or catabolism (Ehrlich pathway) of amino acids. Esters are formed by enzymatic condensation of organic acids and alcohols. The current paper reviews the up-to-date knowledge in the pathways involving the synthesis of higher alcohols and esters by brewing yeasts. Fermentation parameters affecting yeast response during biosynthesis of these aromatic substances are also fully reviewed.Eduardo Pires gratefully acknowledges the Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for the PhD fellowship support (SFRH/BD/61777/2009). The financial contributions of the EU FP7 project Ecoefficient Biodegradable Composite Advanced Packaging (EcoBioCAP, grant agreement no. 265669) as well as of the Grant Agency of the Czech Republic (project GACR P503/12/1424) are also gratefully acknowledged. The authors thank the Ministry of Education, Youth and Sports of the Czech Republic (MSM 6046137305) for their financial support

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

1er. Coloquio de educación para el diseño en la sociedad 5.0

Las memorias del 1er. Coloquio de Educación para el Diseño en la Sociedad 5.0 debenser entendidas como un esfuerzo colectivo de la comunidad de académicos de la División de Ciencias y Artes para el Diseño, que pone de manifiesto los retos y oportunidades que enfrenta la educación en diseño en un contexto de cambio acelerado y rompimiento de paradigmas.El evento se realizó el pasado mes de mayo de 2018 y se recibieron más de 50 ponencias por parte de las profesoras y profesores de la División.Las experiencias y/o propuestas innovadoras en cuanto a procesos de enseñanza y aprendizaje que presentan los autores en cada uno de sus textos son una invitación a reflexionar sobre nuestra situación actual en la materia, y emprender acciones en la División para continuar brindando una educación de calidad en diseño a nuestras alumnas, alumnos y la sociedad.Adicionalmente, se organizaron tres conferencias magistrales sobre la situación actual de la educación en Diseño y de las Instituciones de Educación Superior, impartidas por el Mtro. Luis Sarale, profesor de la Universidad Nacional de Cuyo en Mendoza (Argentina), y Presidente en su momento, de la Red de Carreras de Diseño en Universidades Públicas Latinoamericanas (DISUR), el Dr. Romualdo López Zárate, Rector de la Unidad Azcapotzalco, así como del Mtro. Luis Antonio Rivera Díaz, Jefe de Departamento de Teoría y Procesos del Diseño de la División de la Ciencias de la Comunicación y Diseño, en la Unidad Cuajimalpa de nuestra institución.La publicación de estas memorias son un esfuerzo divisional, organizado desde la Coordinación de Docencia Divisional y la Coordinación de Tecnologías del Aprendizaje, del Conocimiento y la Comunicación, para contribuir a los objetivos planteados en el documento ACCIONES:Agenda CyAD2021, en particular al eje de Innovación Educativa. Es necesario impulsar a todos los niveles de la División espacios de discusión orientados a reflexionar sobre el presente y futuro en la educación del diseñador, que contribuya a mejorar la calidad de la docencia y favorezca al fortalecimiento de los procesos de enseñanza y aprendizaje.Finalmente, extiendo un amplio reconocimiento a todos los miembros de la División que hicieron posible este evento, así como a todos los ponentes y participantes por compartir su conocimiento para que la División sea cada día mejor

Digital rock approach to model the permeability in an artificially heated and fractured granodiorite from the liquine geothermal system (39 degrees s)

The Southern Volcanic Zone of the Andes has a high potential in terms of geothermal resources and is an exceptional and poorly explored natural laboratory to study the interplay between tectonic stresses, thermal damage, low-permeable crystalline rocks, and fluid flow. Permeability is mostly related to the damage zones associated with the faults controlling regional tectonics, namely, the Liquine-Ofqui Fault System and Andean Transverse Faults. This research presents a laboratory approach comprising a characterization of the analogue host rock from a shallow, low-to-medium temperature geothermal system surrounding the Liquine area in Southern Chile (39 degrees S) to better constrain intrinsic and extrinsic factors which allow permeable pathways to exist. We analyse the effect of thermal stress at 25, 150, and 210 degrees C in a granodiorite, measuring some petrophysical properties before and after applying thermal damage, and then loaded the samples until failure. We also compared petrophysical properties with the fracture network characterization using X-ray microcomputed tomography imaging, segmentation, and fluid flow computational simulations. The results show that thermal stress produces intercrystalline microcracks, which result in: (1) an increase in capillary absorption; (2) a decrease in ultrasonic wave velocities; (3) a decrease in compressive strength; (4) a decrease in fracture aperture, and (5) fluid flow simulations indicate that permeability is similar at different temperatures. We conclude that for the granodiorite host rock of the Liquine geothermal system, the combined effect of thermal stress, even at low temperature, may constitute an effective mechanism for sustaining permeability at shallowest depths

The effect of axial stress in maximum sustainable fluid pressure in Andersonian and non-Andersonian crust: A field-based numerical study from the Southern Andes (39 degrees S)

Fracture opening at low differential stress controls maximum sustainable fluid pressure (lambda) within cohesive brittle crust. Standard Andersonian stress states occur when two conditions are met: (1) one of the principal stresses sigma(1)>=sigma(2)>=sigma(3) is vertical, and (2) failure occurs at optimal orientations so that the stress tensor shape ratio phi=(sigma(2)-sigma(3))/(sigma(1)-sigma(3)) is irrelevant. Here we explore the role of phi-values (axial compression, triaxial stress and axial tension) on sustainable fluid pressure driving rock failure under general stress states. We analyzed two exposures representing tectonics of the Southern Andes. Calculated failure curves in lambda-depth space indicate that the hydrostructural behavior of general stress states is governed by the steepest of the principal stresses and the phi-value. Generally, hydrostructural behavior falls within standard Andersonian lambda-depth conditions. However, field examples suggest that non-Andersonian axial stresses may sustain fluid pressures that depart from the standard Andersonian condition: the lowest fluid pressures occur under subvertical axial compression and subhorizontal axial tension; and the highest fluid pressures occur under subvertical axial tension and sub -horizontal axial compression. Since around 15% of global stress compilations correspond to one of these categories, it follows that a significant portion of tectonic regimes potentially define a hydrostructural infrastructure different from standard Andersonian crust.National Agency for Research and Development (ANID), through program ANID-FONDECYT 1180167 ANID Scholarship Program, Beca de Doctorado Nacional 21171178 National Agency for Research and Development (ANID), through the program ANID-FONDAP 1509001